Microfluidic Model of Cystic Fibrosis Bronchi
نویسندگان
چکیده
In this paper we report a microfluidic model to simulate the bronchi of a cystic fibrosis (CF) patient. The biochip is comprised of two cell culture chambers separated by a membrane. On top of the membrane an alginate hydrogel is formed in order to simulate the thick mucus layer spotted in a CF bronchi. In the bottom chamber a monolayer of epithelial cells are cultured to simulate the bronchi tissue. By inoculating the pseudomonas aeruginosa PAO1 strain to the hydrogel layer one can simulate bacterial infections commonly subjected to the CF patient, and the system can be applied for the studies on antibiotic treatment of bacterial infection related to CF.
منابع مشابه
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